Mutations and oncogenes — cause or effect

Somatic mutations and aging: cause or effect?

Aging is a universal, lifelong and inevitable phenomenon, the product of an interaction between genetic, environmental and lifestyle factors. The biological changes that occur during the aging process affect virtually all components of living systems, from the molecular up to that of the whole organism. These changes lead to a breakdown in the normal homoeostatic mechanisms, and so the function...

Genetic Mutations that Cause Coronary Artery Disease

Hypothyroidism and obesity. Cause or effect?

OBJECTIVE To establish relationship between obesity and hypothyroidism and to analyze the frequency the frequency of primary hypothyroidism in obese patients and frequency of obesity in primary hypothyroidism patients. METHODS We conducted this retrospective, observational study in the Department of Endocrinology and Obesity Clinic, Medwin Hospital, Hyderabad, India in Mar 2008. In the last 1...

Depression and the hippocampus: cause or effect?

f d f h l s R esearch examining the relationship between major depressive disorder (MDD) and hippocampal volume has long wrestled with the chicken and egg question. From the time the rst report was published finding smaller hippocampal volumes in atients with MDD compared with healthy control subjects (1), here have been hundreds of studies in the literature, with the ajority, but not all, find...

Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa.

Defects of the V-type proton (H+) ATPase (V-ATPase) impair acidification and intracellular trafficking of membrane-enclosed compartments, including secretory granules, endosomes, and lysosomes. Whole-exome sequencing in five families affected by mild to severe cutis laxa, dysmorphic facial features, and cardiopulmonary involvement identified biallelic missense mutations in ATP6V1E1 and ATP6V1A,...